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PIWIL4 Maintains HIV-1 Latency by Enforcing Epigenetically Suppressive Modifications on the 5' Long Terminal Repeat.
He Z, Jing S, Yang T, Chen J, Huang F, Zhang W, Peng Z, Liu B, Ma X, Wu L, Pan T, Zhang X, Li L, Cai W, Tang X, Zhang J, Zhang H. He Z, et al. J Virol. 2020 May 4;94(10):e01923-19. doi: 10.1128/JVI.01923-19. Print 2020 May 4. J Virol. 2020. PMID: 32161174 Free PMC article.
Although substantial progress has been made in depicting the molecular pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection, the comprehensive mechanism of HIV-1 latency and the most promising therapeutic strategies to effectively reactivate the HIV-1 latent rese …
Although substantial progress has been made in depicting the molecular pathogenesis of human immunodeficiency virus type 1 (HIV-1) infection …
CRNDE Promotes Malignant Progression of Glioma by Attenuating miR-384/PIWIL4/STAT3 Axis.
Zheng J, Liu X, Wang P, Xue Y, Ma J, Qu C, Liu Y. Zheng J, et al. Mol Ther. 2016 Aug;24(7):1199-1215. doi: 10.1038/mt.2016.71. Epub 2016 Apr 8. Mol Ther. 2016. PMID: 27058823 Free PMC article. Retracted.
At the molecular level, treatment by CRNDE knockdown or miR-384 overexpression resulted in a decrease of piwi-like RNA-mediated gene silencing 4 (PIWIL4) protein. Besides, PIWIL4 was identified as a target of miR-384 …
At the molecular level, treatment by CRNDE knockdown or miR-384 overexpression resulted in a decrease of piwi-like RNA- …
piR-31470 epigenetically suppresses the expression of glutathione S-transferase pi 1 in prostate cancer via DNA methylation.
Zhang L, Meng X, Pan C, Qu F, Gan W, Xiang Z, Han X, Li D. Zhang L, et al. Cell Signal. 2020 Mar;67:109501. doi: 10.1016/j.cellsig.2019.109501. Epub 2019 Dec 16. Cell Signal. 2020. PMID: 31837464
Functional inactivation of GSTP1 increases the susceptibility to oxidative stress and enhance progression risk of the prostatic carcinoma. In this study, we hypothesized that the Piwi-interacting RNA (piRNA) could be a sequence-recognition and guidance molecule for inducti …
Functional inactivation of GSTP1 increases the susceptibility to oxidative stress and enhance progression risk of the prostatic carcinoma. I …
Whole-exome sequencing of a cohort of infertile men reveals novel causative genes in teratozoospermia that are chiefly related to sperm head defects.
Li Y, Wang Y, Wen Y, Zhang T, Wang X, Jiang C, Zheng R, Zhou F, Chen D, Yang Y, Shen Y. Li Y, et al. Hum Reprod. 2021 Dec 27;37(1):152-177. doi: 10.1093/humrep/deab229. Hum Reprod. 2021. PMID: 34791246
MAIN RESULTS AND THE ROLE OF CHANCE: We identified rare and deleterious variants of piwi like RNA-mediated gene silencing 4 (PIWIL4: 1/82 patients, 1.21%), coiled-coil and C2 domain containing 1B (CC2D1B: 1/82 patients, 1.21 …
MAIN RESULTS AND THE ROLE OF CHANCE: We identified rare and deleterious variants of piwi like RNA-mediated ge …
Cutting edge: KIR antisense transcripts are processed into a 28-base PIWI-like RNA in human NK cells.
Cichocki F, Lenvik T, Sharma N, Yun G, Anderson SK, Miller JS. Cichocki F, et al. J Immunol. 2010 Aug 15;185(4):2009-12. doi: 10.4049/jimmunol.1000855. Epub 2010 Jul 14. J Immunol. 2010. PMID: 20631304 Free PMC article.
Although silencing of individual KIR genes is strongly correlated with the presence of CpG dinucleotide methylation within the promoter, the mechanism responsible for silencing has not been identified. Our results show that antisense transcripts mediate KIR transcri …
Although silencing of individual KIR genes is strongly correlated with the presence of CpG dinucleotide methylation within the promot …
piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine.
Han R, Zhang L, Gan W, Fu K, Jiang K, Ding J, Wu J, Han X, Li D. Han R, et al. Prostate. 2019 May;79(7):798-812. doi: 10.1002/pros.23786. Epub 2019 Mar 22. Prostate. 2019. PMID: 30900311
RESULTS: The downregulated expression of piRNA-DQ722010 was the most significant in piRNA microarray analysis in 10 mug/L MC-LR treated group, while Pik3r3 was significantly upregulated, consistent with the results that a distinct prostatic epithelial hyperplasia was observed and …
RESULTS: The downregulated expression of piRNA-DQ722010 was the most significant in piRNA microarray analysis in 10 mug/L MC-LR treated grou …
HIWI2 induces G2/M cell cycle arrest and apoptosis in human fibrosarcoma via the ROS/DNA damage/p53 axis.
Das B, Sahoo S, Mallick B. Das B, et al. Life Sci. 2022 Mar 15;293:120353. doi: 10.1016/j.lfs.2022.120353. Epub 2022 Jan 21. Life Sci. 2022. PMID: 35074406
AIMS: Piwi-like RNA-mediated gene silencing 4 (PIWIL4) or HIWI2, are seen deregulated in human cancers and possibly play critical roles in tumorigenesis. ...Furthermore, an increase in H2AX phosphorylation was observed, whic …
AIMS: Piwi-like RNA-mediated gene silencing 4 (PIWIL4) or HIWI2, are seen deregulate …
Andrology of two hidden clinical subgroups among men with idiopathic cryptozoospermia.
Schülke LC, Wistuba J, Nordhoff V, Behre HM, Cremers JF, Kliesch S, Di Persio S, Neuhaus N. Schülke LC, et al. Hum Reprod. 2024 Feb 14:deae013. doi: 10.1093/humrep/deae013. Online ahead of print. Hum Reprod. 2024. PMID: 38365879
On the selected cohort of 39 patients (12 Control, 27 cryptozoospermic), we performed immunohistochemistry for spermatogonial markers melanoma-associated antigen 4 (MAGEA4) and piwi like RNA-mediated gene silencing 4 (PIW …
On the selected cohort of 39 patients (12 Control, 27 cryptozoospermic), we performed immunohistochemistry for spermatogonial markers melano …